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Using Bitter Taste Receptor Blockers to Improve the Palatability of Pediatric Medicines

RecruitingNAAges 18 Years - 60 YearsAllMonell Chemical Senses Center
NCT06929455 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Many people, particularly small children, must take drugs in liquid form because they cannot swallow pills or capsules. The bad taste of some liquid drugs can keep patients from taking drugs they need for their health. Our main goal in this research study is find ingredients that might make drugs taste better. Participants in this research study will be healthy adults between the ages of 18 and 60 years old. Participants will taste samples (liquids or gels) containing active pharmaceutical ingredients (substances in medications that produce desired health effects). After tasting each sample participants will spit out the sample and rinse with water (no samples will be swallowed). Active pharmaceutical ingredients of current interest are: 1) tenofovir alafenamide, used to treat HIV infection and hepatitis B, 2) rifampicin, used to treat tuberculosis, 3) rifapentine, used to treat tubercu

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📋 Eligibility rules (as published)
Inclusion Criteria: * Between the ages of 18 and 60; * Generally healthy by self-report; * All races/ethnicities, both men and women; * Able to provide informed consent; * Able to attend repeated visits to Monell for sensory testing; * Willing to follow instructions (e.g., refrain from eating or drinking for at least 1 hour before sessions, willing to remain on site for one hour after tasting an API that the participant has never tasted before). - Exclusion Criteria: * Under 18 or over 60; * Pregnant, nursing, or plans to become pregnant; * Unable to provide consent (including limited ability to understand written and spoken English); * Tobacco, vape, marijuana, or tetrahydrocannabinol cartridge users. We will accept people who have used tobacco or marijuana products on occasion, but not regular users; * Known drug or food allergies of any kind; * Diabetes or other metabolic disorder; * Liver issues of any kind, including viral hepatitis; * Kidney issues of any kind; * Other chronic illness, including cardiovascular, neurological, immune disorders, or any other serious acute or chronic condition * Dentures or other major dental implants; * Condition affecting the oral cavity, including dry mouth, burning mouth syndrome, active sores or blisters, geographic tongue, or other disorders * Current infection or cold, flu, or infection with SARS-CoV-2 within the last four weeks; * Unable to taste or smell * Daily use, or use within the last four weeks, of either prescription or over-the-counter medications (except for birth control) * History of tuberculosis (including latent tuberculosis), positive skin or other tuberculosis test at any time in the past, birth in or residence in a country with high tuberculosis rates, known contact with someone who is tuberculosis positive * HIV infection
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What it tests

  • Flavor additives
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Where

1 site
Monell Chemical Senses Center
Philadelphia, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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