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Impact of Intravitreal Faricimab on Renal Function in Diabetic Patients

RecruitingNAAges any - anyAllUniversity Hospital, Alexandroupolis
NCT06929507 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to investigate the impact of intravitreal injection of anti-vascular endothelial growth factor (anti VEGF) Faricimab on renal function of diabetic patients. Faricimab is a new anti-VEGF drug which inhibits both VEGF-A and Ang-2 and it is used for the treatment of diabetic macular edema and neovascular age related macular degeneration. It is known that previous anti-VEGF agents has systematic absorption and may cause deterioration in renal function of the patients. However, the effect of Faricimab on kidney function has not been investigated yet. Taking into account that Ang-2 has destructive effect on kidneys, the investigation of the effect of its inhibition in diabetic patients who have already renal function deterioration may provide a valuable information in scientific community.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with diabetes * Patients with DME or nAMD or macular edema secondary to retinal vein occlusion * Patients already receiving nephroprotective drugs Exclusion Criteria: * Patients with end stage renal disease * Pregnancy * Patients with other retinal disorders * Previous renal transplantation Patients under hemodialysis
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What it tests

  • Intravitreal injection of Faricimab or Aflibercept 2 mg
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Where

2 sites
University Hospital of Alexandroupolis
Alexandroupoli, Greece
University Hospital of Alexandroupolis
Alexandroupoli, Greece
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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