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The NACHO Trial (Nut Allergy Children OIT)

RecruitingNAAges 1 Year - 17 YearsAllHUS Skin and Allergy Hospital
NCT06930950 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Most food allergies that begin in early childhood are mild and resolve by school age, but nut allergies persist in about 80-90% of individuals into adulthood. The consumption of nuts, particularly cashew nuts, has increased dramatically in Finland in the 21st century, leading to a rise in severe allergic reactions to cashew nuts among young children. Of the food anaphylaxis cases reported in the Finnish Anaphylaxis Registry between 2015-2020, 49% were caused by nuts, with cashew nuts being the most common trigger. The standard treatment for nut allergies is strict avoidance of nuts and symptom management with emergency medications. Oral immunotherapy (OIT) is a food allergy treatment that increases tolerance, and it has primarily been studied in school-aged children, with desensitization achieved in about 80% of cases. Permanent tolerance, depending on the allergen, develops in 30-50% o

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age 6 months - 17 years 2. Sensitization to cashew nut (allergen-specific IgE or positive skin PRICK test) 3. Positive oral food challenge for cashew nut Exclusion Criteria: 1. Poor adherence 2. Uncontrolled or severe asthma 3. Uncontrolled active or severe or atopic dermatitis 4. Chronic urticaria 5. Eosinophilic esophagitis or other gastrointestinal eosinophilic disorders 6. Active malignant neoplasia 7. Active systemic, autoimmune disease 8. Diabetes treated with insulin 9. Severe systemic illness or severe medical conditions such as cardiovascular or lung diseases 10. Medication with beta blockers 11. Medication with ACE-inhibitors 12. Mastocytosis 13. Pregnancy or breastfeeding 14. Language barriers (not fluent Finnish or Swedish)
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What it tests

  • Cashew nut oral immunotherapy
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Where

1 site
HUS Skin and Allergy Hospital
Helsinki, Finland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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