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Reprogramming Energy Homeostasis in Overweight Individuals Via Exercise, Cognitive, and Social Training

RecruitingNAAges 6 Years - 11 YearsAllBambino Gesù Hospital and Research Institute
NCT06931730 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The RESILIENT project is a clinical trial investigating leptin sensitivity in both children and adults with overweight or obesity. The study examines the additive effects of Cognitive Training (CT) and Social Training (ST) on leptin sensitivity, compared to stand-alone Intensive Health Behaviour Treatment (IHBT), which includes diet and Physical Activity (PA). The intervention will last for 8 weeks, followed by a 12-week washout period. A multilevel assessment will be conducted, evaluating in vivo leptin sensitivity (through the ratio of leptin levels to caloric intake) as well as ex vivo molecular analysis of leptin signaling in Peripheral Blood Mononuclear Cells (PBMCs). Additionally, clinical, psychological, cognitive, and physiological assessments will be performed to assess the efficacy of each intervention. By investigating leptin resistance as a potential molecular bridge between

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📋 Eligibility rules (as published)
Inclusion Criteria: * a condition of overweight or obesity * Intelligence Quotient (IQ) ≥ 85 Exclusion Criteria: * genetic or syndromic obesity; * reduced mobility; * systemic diseases; * ongoing pharmacological treatment for chronic conditions.
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What it tests

  • Nutritional Intervention
  • Physical Activity training
  • Cognitive training
  • Social Training
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Where

2 sites
Ospedale Pediatrico Bambino Gesù
Rome, Italy
Bambino Gesù Hospital and Research Institute,
Rome, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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