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Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis

RecruitingNAAges 18 Years - anyAllUniversity Hospital Ostrava
NCT06933199 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This multicentre proof-of-concept study, involving 4 centers, aims to establish the value of fractionated neoadjuvant stereotactic radiotherapy (NaSRT) as a new treatment paradigm for brain metastases (BM) in the frame of the Czech neurooncology network. Most relevant studies published to date used single-fraction radiotherapy and dealt with the inherent bias related to their retrospective nature. The researchers aim to increase the level of evidence for this treatment paradigm together with other similar ongoing studies.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * Karnofsky Performance Status ≥ 60 * Histologically verified primary cancer disease * MRI findings indicating BM * Target BM indicated for surgical resection and any other metastases suitable for radical SRT. * Target BM between 1 cm and 7 cm at the longest diameter on T1 post-contrast MR imaging Exclusion Criteria: * Confirmed hematological malignity * Small-cell (lung) carcinoma * Peracute condition requiring immediate neurosurgical intervention * History of whole-brain radiotherapy (WBRT) * History of stereotactic radiotherapy to a target brain metastasis * Pregnancy * Inability to perform surgical resection of the target BM within 7 days after NaSRT
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What it tests

  • Neoadjuvant Stereotactic Radiotherapy (NaSRT)
  • Postoperative Stereotactic Radiotherapy (SRT)
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Where

4 sites
University Hospital Ostrava
Ostrava, Czechia
Masaryk Memorial Cancer Institute
Brno, Czechia
University Hospital Hradec Králové
Hradec Králové, Czechia
University Hospital Olomouc
Olomouc, Czechia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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