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Losartan to Improve Outcomes After Multi-ligament Knee Injury

RecruitingPhase 2Ages 18 Years - 40 YearsAllBrigham and Women's Hospital
NCT06933706 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Multi-ligament knee injuries (MLKIs) can occur during military training, sports injuries, or traumatic events such as motor vehicle accidents and can be devastating events. These complex injuries involving disruption of 2 or more ligaments often coincide with injuries to arteries, nerves, tendons, menisci, and/or fractures and can be devastating events. MLKIs often require complex treatments nearly 2 in 5 patients suffer complications after surgery. Loss of knee range of motion is the most common complication and is associated with military separation. There are also long-term effects of motion loss, as the need for motion-restoring surgery after MLKI is associated with an increased risk of osteoarthritis within 5 years of surgery. A person's ability to perform both activities of daily living and higher demand physical activities is often impaired both in the short and long term. In fact

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📋 Eligibility rules (as published)
Inclusion Criteria: * Multi-ligament knee injury defined as a complete grade III injury of 2 or more ligaments * At least one ligament surgically reconstructed or repaired * Willingness to comply with the study protocol and assessments Exclusion Criteria: * Allergic to any active or inactive ingredient of losartan * Pregnant, planning to become pregnant, or sexually active females choosing not to use effective means of contraception during the 30-day course of losartan * Those at increased risk of losartan related side effects including those with severe renal insufficiency, hepatic disease, hypotension, and/or hyperkalemia * Have a history of prior knee ligament surgery of the involved knee * Undergoing staged surgical procedures in the treatment of MLKI * Have a traumatic brain injury that limits their ability to participate in their postoperative care or any condition that would preclude the ability to comply with postoperative rehabilitation * Have a concomitant injury or underwent a surgical procedure that will preclude the ability to perform range of motion exercises (i.e. surgery for extensor mechanism rupture or avulsion, vascular graft surgery)
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What it tests

  • losartan 25 mg
  • Placebo capsule
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Where

3 sites
University of Kentucky
Lexington, United States
Walter Reed National Military Medical Center
Bethesda, United States
Mass General Brigham
Foxborough, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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