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Cognitive Remediation Therapy for Schizophrenia: Effects on EEG and Emotional Regulation

RecruitingNAAges 18 Years - 55 YearsAllBeykoz University
NCT06936397 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to determine whether Cognitive Remediation Therapy (CRT) can improve attention, memory, and emotional regulation in people with schizophrenia. CRT is a structured program that includes exercises to strengthen cognitive skills such as problem-solving, working memory, and emotion regulation. The study will recruit 60 participants: 30 individuals with schizophrenia and 30 healthy individuals of similar age and gender. Those with schizophrenia will be randomly assigned to either receive CRT or be placed on a waitlist without therapy. All participants will undergo non-invasive brain activity (EEG) and emotional response (GSR) recordings before and after the therapy. The study's main question is: Does participating in a 12-week CRT program improve brain-based markers of attention and emotional regulation in people with schizophrenia? Additional tests, such as memory and emot

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📋 Eligibility rules (as published)
Inclusion Criteria (Schizophrenia Group): * Diagnosed with schizophrenia according to DSM-5 criteria * Age between 18 and 55 years * Clinically stable (no hospitalization or medication change within 1 month) * Minimum primary school education * Able to provide informed consent * Right-handed (for EEG protocol consistency) Inclusion Criteria (Healthy Control Group): * No history of psychiatric or neurological disorders * Age- and gender-matched to schizophrenia group * No current medication affecting CNS * Able to provide informed consent * Right-handed Exclusion Criteria (Both Groups): * Current or past substance use disorder (within the past year) * Comorbid neurological illness (e.g., epilepsy, traumatic brain injury) * Current use of benzodiazepines or medications that significantly affect cognitive function * Intellectual disability or MoCA score \< 20 * Visual or hearing impairments that could interfere with task performance * Participation in a psychological intervention in the last 3 months
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What it tests

  • Cognitive Remediation Therapy
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Where

1 site
Beykoz University
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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