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Comparison of 40% Glucose Solution and Autologous Blood Patch Pleurodesis for Postoperative Air Leak After Lung Resections

RecruitingNAAges 18 Years - anyAllWielkopolskie Centrum Pulmonologii i Torakochirur…
NCT06936969 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Prolonged or persistent air leak (PAL) is one of the most common complications in patients after surgery on the lung parenchyma. Air leaks typically originate from alveolar-pleural fistulas, which can result from surgical manipulation of the lung parenchyma or the bronchial stump after procedures such as lobectomy. Key risk factors for PAL include extensive lung resections such as lobectomy, presence of pleural adhesions, incomplete interlobar fissures, chronic obstructive pulmonary disease (COPD), asthma, emphysema, advanced age, and reduced preoperative lung function, particularly low preoperative FEV1 values. PAL necessitates extended pleural drainage, leading to significant patient discomfort, pain, and substantial limitations in early postoperative rehabilitation. In patients with pre-existing pulmonary conditions like bronchial asthma or COPD, PAL can markedly worsen clinical stat

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age: patients aged 18 years or older. * Surgical Procedure: patients who underwent anatomical lung resections (segmentectomy, lobectomy, or bilobectomy) at the Department of Thoracic Surgery, Poznan University of Medical Sciences, between November 2023 and December 2024. * Prolonged Air Leak Diagnosis: patients with diagnosed PAL after lung resection, as defined by air leakage persisting beyond 5 days post-surgery. * Consent: patients who were willing to provide informed consent for participation in the study and for the intervention procedures (autologous blood pleurodesis or 40% glucose solution pleurodesis). Exclusion Criteria: * Non-Anatomical Resections: Patients who underwent non-anatomical resections, such as pneumonectomy, lung transplantation, sleeve resections, or wedge resections. * Patients from whom the required volume of peripheral blood (120 ml) could not be collected. * Active Infection or Sepsis: Patients with ongoing infections or sepsis at the time of enrollment. * Reoperation or Additional Interventions: patients who required immediate reoperation or other interventions that disturb the process of treating PAL. * Mental Health or Cognitive Impairment: patients with significant cognitive impairments or mental health conditions that hinder the ability to provide informed consent or comply with study procedures. * Patients who failed to perform three ABPP or 40% glucose injections (no consent, need for urgent surgery).
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What it tests

  • Autologous blood patch pleurodesis
  • 40% glucose solution pleurodesis
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Where

1 site
Wielkopolskie Centrum Pulmonologii i Torakochirurgii
Poznan, Poland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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