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Delivery and Implementation of a Randomised Crossover Trial on Thrombosis

RecruitingNAAges 60 Years - 120 YearsAllQueen Mary University of London
NCT06937372 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

What is the Study About? The DIRECT study (Delivery and Implementation of a Randomised Crossover Trial on Thrombosis) is a large research project investigating the best way to prevent blood clots (thrombosis) in people who break their hip. The study will compare two common treatments: aspirin (a tablet) and low molecular weight heparin (LMWH, an injection). Every year, thousands of people in the UK suffer a hip fracture, which often requires surgery and hospital care. After a hip fracture, patients are at risk of developing serious blood clots in their legs (deep vein thrombosis, DVT) or lungs (pulmonary embolism, PE), which can be life-threatening. Currently, doctors prescribe different medications to prevent these clots, but there is uncertainty about which treatment is best for people with hip fractures. Why is This Study Needed? Blood clot prevention is vital for hip fracture patie

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults from 60 to 150 years sustaining fragility hip fracture identified by their entry into UK hip registries. Exclusion Criteria: * Individuals who do not meet the eligibility criteria to be enrolled in the NHFD and SHFA registries Hip fracture individuals above 150 years of age.
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What it tests

  • Patients in hospitals allocated to this arm will receive aspirin as their routine thromboprophylaxis after surgery.
  • Low molecular weight heparin (LMWH)
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Where

1 site
Whipps Cross University Hospital
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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