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Optimised Decrement Evoked Potential (DeEP) Mapping to Guide Ventricular Tachycardia (VT) Ablation in Patients With Structural Heart Disease VT

RecruitingNAAges 18 Years - anyAllUniversity Hospitals Coventry and Warwickshire NHโ€ฆ
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In plain words

What the trial is, and whether it could suit you

Ventricular tachycardia (VT) is a life-threatening heart rhythm disorder. Special pacemakers called implantable cardiac defibrillators (ICDs) help treat VT episodes, however they do not prevent the VT episodes from occurring. Catheter ablation for VT is a minimally-invasive and established procedure for preventing VT recurrence. This involves placing wires in the heart to find the diseased areas that are responsible for the VT episodes. The diseased areas are shown on computer-generated maps and are later removed via controlled tissue heating (ablation). A major challenge during the VT ablation procedure is locating the diseased area responsible for the VT episodes. Several methods have been described to locate the diseased heart area, however these methods are not always effective. In this study, we aim to improve the identification of the diseased heart areas responsible for the VT ep

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * โ‰ฅ18 years old * Patients with cardiac implantable electronic devices (CIED) (e.g. pacemakers, cardiac resynchronisation therapy (CRT) devices, implantable cardioverter defibrillator (ICD) devices) * Eligible for VT ablation as part of standard care (urgent or elective) * Ischaemic heart disease and prior myocardial infarction (MI) (using the international definition of MI: Q waves or imaging evidence of regional myocardial akinesis/thinning in the absence of a non-ischemic cause with documentation of prior ischaemic injury) OR other structural heart disease (such as: arrhythmogenic cardiomyopathy (ACM), or dilated cardiomyopathy (DCM), or hypertrophic cardiomyopathy (HCM), or sarcoidosis, or myocarditis). * Catheter ablation of VT ablation using Abbott intracardiac mapping catheter and Ensite intracardiac mapping system. Exclusion Criteria: * Lacks capacity to provide informed consent * New York Heart Association (NYHA) class IV heart failure * Life expectancy of less than 12 months * Implanted with a ventricular assist device * Presence of mobile intracardiac thrombus * Reversible cause of VT * Women who are pregnant or nursing * Both mechanical aortic and mitral valves * Enrolment in a concurrent interventional clinical study that in the judgement of the investigator would increase risk to the patient or deem the patient inappropriate to participate in this study.
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What it tests

  • Optimised DeEP-guided ablation
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Where

1 site
University Hospitals Coventry & Warwickshire NHS Trust
Coventry, United Kingdom
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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