The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.

Inclusion Criteria: 1. Age: Adults aged 18 years and older. 2. Type of Cardiac Arrest: Patients who have experienced a non-traumatic out-of-hospital cardiac arrest. 3. CPR Administration: Patients receiving cardiopulmonary resuscitation from an advanced life support (ALS) team. 4. Intubation and Ventilation: Patients who are intubated and ventilated during resuscitation efforts. Exclusion Criteria: 1. Cardiac arrest in patient younger than 18 years of age. 2. Traumatic cardiac arrest, including drowning, penetrating or blunt injury, and burns. 3. Immediate Return of Spontaneous Circulation (ROSC): Patients who achieve ROSC before intubation and initiation of intubation. 4. Pregnancy. 5. Mechanical ventilation during arrest: patients already receiving mechanical ventilation at the moment of cardiac arrest, due to reasons other than their arrest, will be excluded. 6. Do Not Resuscitate (DNR) Orders: Patients with existing DNR orders or any advanced directive indicating that CPR should not be performed. 7. Failure to intubate: if intubation is unsuccessful, ventilation by any means (MBV, SGA) should take priority over the study protocol, and the patient is excluded. 8. Enrolment in Other Studies: Patients currently enrolled in another interventional clinical trial that could interfere with the outcomes of this study.