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Cardiometabolic evalUation REgistry of Heart Failure

Recruitingn/aAges 18 Years - anyAllRuijin Hospital
NCT06939985 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a combined retrospective-prospective observational cohort study investigating the role of systemic and local cardiometabolic risk factors in cardiac structural/functional remodeling and clinical outcomes among heart failure (HF) patients. The study integrates retrospective clinical data (from the past 10 years) and prospective longitudinal follow-up (5 years) of HF patients across HF with reduced (HFrEF), mildly-reduced (HFmrEF), preserved (HFpEF) and improved ejection fraction (HFimpEF) phenotypes. Systemic metabolic factors (e.g., blood lipid profiles, glycemic levels, insulin resistance) and local factors (e.g., epicardial adipose tissue \[EAT\], perivascular adipose tissue \[PVAT\]) will be analyzed for their associations with changes in cardiac geometrics and function, dynamic transitions between HF phenotypes, as well as the occurrence of major adverse cardiovascular events

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age ≥ 18 years 2. Chronic HF (NYHA II\~IV), including: * HFrEF (HF with reduced ejection fraction): ① HF symptoms±signs ; ② LVEF≤40%. * HFimpEF (HF with improved ejection fraction): ① HF symptoms±signs; ② previous LVEF ≤ 40% and a follow-up measurement of LVEF \>40%. * HFmrEF (HF with mildly reduced ejection fraction): ① HF symptoms±signs; ② LVEF 41%\~49%. * HFpEF (HF with preserved ejection fraction): ① HF symptoms±signs; ② LVEF ≥50%; ③ objective evidence of cardiac structural and/or functional abnormalities consistent with the presence of LV diastolic dysfunction/raised LV filling pressures, including raised natriuretic peptide. Exclusion Criteria: 1. Estimated survival ≤ 1 year. 2. Pregnant or lactation, or have the intention to give birth within one year. 3. Poor compliance, unable to follow-up. 4. Mental or physical status not allowing written informed consent. 5. Unwillingness to give informed consent.
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What it tests

  • Not listed
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Where

1 site
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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