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Study of Abnormally Fertilized Embryos

Recruitingn/aAges 18 Years - 49 YearsAllIgenomix
NCT06940973 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to determine the diploidy rate of haploid and triploid embryos from in vitro fertilization (IVF) cycles. The main questions it aims to answer are: * Can a molecular genetic fertilization check of abnormally fertilized embryos be used to expand opportunities for couples undergoing assisted reproduction treatment? * Is the chromosomal loss or gain present in abnormally fertilized embryos predominantly maternal in origin? For this purpose, we will evaluate the morphokinetics and ploidy of about 300 embryos with different types of abnormal pronuclear patterns (1PN, 2.1PN, and 3PN) that reach the blastocyst stage. Whenever possible, embryos with a non-diploid chromosomal complement will also be assessed to determine the origin (maternal or paternal) of the chromosomal set that has been lost or gained. Study subjects will follow their previously sched

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📋 Eligibility rules (as published)
Inclusion Criteria: * ART patients who sign the Informed Consent of the study. * Age: oocytes from women ≤ 49 years and semen from men ≤ 60 years. Donation of gametes is allowed. * ≥1 blastocysts from oocytes with an abnormal pronuclear pattern (1PN, 2.1PN, and/or 3PN) and with the presence of 2 polar bodies (PB), cultured in a time-lapse incubator. Exclusion Criteria: * No exclusion criteria have been considered for this study.
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What it tests

  • Parental samples
  • PGT-A
  • TE rebiopsies and spent blastocyst media collection
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Where

1 site
Equipo Médico Crespo Valencia
Valencia, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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