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Platelet-Rich Fibrinogen in Extraction Socket Healing of the Aged

RecruitingNAAges 14 Years - 80 YearsAllUniversity of Nebraska
NCT06943846 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to better understand oral wound healing in the aged participant following placement of platelet-rich fibrinogen (PRF). In this study, 12 participants requiring a posterior tooth extraction will be enroll: 6 participants aged 14-18, 6 participants aged 50-80. All will undergo a posterior tooth extraction with a small tissue specimen taken from the extraction site. Half of the participants will also have their blood drawn and platelet-rich fibrinogen placed in the extraction socket. Participants will return in 2 weeks for suture removal and another soft tissue sample. Participants will return at 3 months for a final post-operative radiograph. All soft tissue samples will undergo immunofluorescence.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient at University of Nebraska Medical Center (UNMC) College of Dentistry * Requires extraction of posterior tooth * Able and willing to provide consent/assent Exclusion Criteria: * Systemic conditions that delay wound healing * Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs), methotrexate, bisphosphonates or other drugs that inhibit wound healing Smoking and vaping Pregnancy
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What it tests

  • Platelet-rich fibrin (PRF)
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Where

1 site
University of Nebraska Medical Center College of Dentistry
Lincoln, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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