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Conditioning Regimen in Elderly AML Patients Receiving Haplo-HSCT.

RecruitingNAAges 55 Years - anyAllPeking University People's Hospital
NCT06946602 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Elderly AML patients receiving conventional chemotherapy have poor prognosis. Allo-HSCT offers better long-term survival than chemotherapy, while high TRM limits its use. Current research focuses more on improving conditioning regimens to reduce TRM. Studies suggest Bu/Flu/Cy/ATG are safer and more effective for elderly AML haplo-HSCT, lowering TRM. However, prospective randomized trials are lacking. This study aims to compare Bu/Flu/Cy/ATG vs. Bu/Cy/ATG to determine if TRM can be reduced in elderly AML undergoing haplo-HSCT.

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📋 Eligibility rules (as published)
Inclusion Criteria: \- (a)Diagnosed with AML in first complete remission (CR1). (b)Age ≥55 years. (c)Availability of an haploidentical donor, first transplant, no matched sibling or unrelated donor. (d)Willingness to provide written informed consent. Exclusion Criteria: * (a) Uncontrolled active infection. (b) Secondary AML. (c)Refusal to provide informed consent.
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What it tests

  • Bu/Flu/Cy/ATG
  • Bu/Cy/ATG
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Where

1 site
Peking University People's Hospital
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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