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Deciphering the Genetic Architecture of Autoimmune Diseases

Recruitingn/aAges 18 Years - 115 YearsAllNational Human Genome Research Institute (NHGRI)
NCT06948110 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Autoimmune diseases can be caused by genes people inherit from their parents. The gene changes that cause these diseases have been well studied in people with European and Asian ancestors. But some diseases behave differently in people who are native to North and South America. Researchers want to know more about the gene changes and other factors that may cause autoimmune diseases among these people. This project will be based in Peru. Objective: To study how gene changes can lead to autoimmune diseases in people native to Peru. Eligibility: People aged 18 years and older with an autoimmune disease. These may include systemic lupus erythematosus; Sjogren disease; scleroderma; rheumatoid arthritis; seronegative spondylo-arthropathies; and systemic vasculitis. Family members and healthy volunteers are also needed. Design: Participants will have 2 clinic visits; these wi

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📋 Eligibility rules (as published)
* INCLUSION CRITERIA: Any person who meets the criteria for inclusion in the study will be considered and must have the patient's signed informed consent for participation. Autoimmune Disease Diagnosis: Cases: * Patients diagnosed with SLE, Sjogren's disease, scleroderma, rheumatoid arthritis, seronegative spondyloarthropathies, and systemic vasculitis, as defined by the American College of Rheumatology classification criteria. * Over 18 years old Controls: * Family members of identified cases, and unrelated individuals. The controls would be from the same community as the patients and families studied, and of the same age and gender. Screening for autoimmune diseases and allergic diseases will be performed. * Over 18 years old EXCLUSION CRITERIA: -People diagnosed with a chronic viral disease: HIV, hepatitis C or HTLV-1.
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What it tests

  • Not listed
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Where

2 sites
National Human Genome Research Institute (NHGRI)
Bethesda, United States
Amazon Rainforest
Lima, Peru
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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