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Impact of rTMS on BCI Control in Upper Limb Motor Rehabilitation of Patients With Chronic Stroke

RecruitingNAAges 18 Years - 85 YearsAllInstitut National de la Santé Et de la Recherche …
NCT06951035 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cerebrovascular accidents (strokes) are a major public health issue. Stroke is the 3rd leading cause of death and the leading cause of disability and loss of autonomy. In France, there are currently 130,000 new cases per year, and the aging of the population will lead to an increase in this number over the next few years. Among post-stroke impairments, motor deficit of the upper limb is the most common disability, affecting 73-88% of first-time stroke patients and 55-75% of chronic patients. Associated deficits can complicate rehabilitation management and affect recovery. The clinical profile of patients with motor deficits is therefore varied and complex, requiring an individualized approach. At present, only physiotherapy is recommended, with modest results. Repeated transcranial magnetic stimulation is a therapy that can improve motor recovery, but currently has a low level of eviden

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📋 Eligibility rules (as published)
Inclusion Criteria: * Single Stroke older than 6 months * Distal motor deficit of the upper limb (UE-FMA score \< 53) with visible extension of the fingers (Medical Research Council (mRC) score ≥ 2) * Right-handed * Between 18 and 85 years of age * Having given their written consent Exclusion Criteria: * Patient under tutorship or guardianship, under safeguard of justice, deprived of liberty, pregnant or breast feeding women * Life-threatening pathologies or compromising follow-up during the study period * Trouble of understanding : score below 12/15 in the Boston Diagnostic Aphasia Examination (BDAE) order execution test * Fixed spasticity of finger or carpal flexors (mAS score = 4) or botulinum toxin injection less than 12 weeks old in the forearm or hand * History of degenarative neurological pathology or craniectomy * Deficient upper limb skin lesion preventing use of mucle stimulation * Skin lesion of the scalp preventing EEG placement * Participation in biomedical therapeutic research that may affect the recovery of the deficient hand during the study * Patient who has previously participated in a therapeutic study rTMS (excluding single shock) or a BCI * Patient who does not wish to be informed of a brain abnormality discovered accidentally on MRI
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What it tests

  • Repetitive transcranial magnetic stimulation (rTMS)
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Where

1 site
Institut du Cerveau
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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