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The Impact of Daily Intake of Short-chain Fatty Acids on Cardiometabolic Risk Factors in Individuals at Risk for Metabolic Syndrome

RecruitingNAAges 18 Years - 65 YearsAllKU Leuven
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In plain words

What the trial is, and whether it could suit you

During this study, the effect of short-chain fatty acids on blood lipaedemia, glycemia, anthropometrics, blood pressure and energy expenditure will be investigated.

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📋 Eligibility rules (as published)
Inclusion Criteria: * male and female participants * central obesity ( BMI ≥ 25 kg/m² or waist circumference ≥ 80 cm for women/ ≥ 94 cm for men) * One additional risk factor for metabolic syndrome: 1. Insulin resistance (HOMA-IR ≥ 1.7 or fasting glucose ≥ 100 mg/dl) 2. Triglyceride concentration ≥ 150 mg/dl 3. HDL-cholesterol \< 40 mg/dl for women/ \< 50 mg/dl for men 4. Systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg * knowledge of English Exclusion Criteria: * gastrointestinal disorders such as IBD, IBS, celiac disease, chronic constipation, chronic diarrhoea * history of abdominal surgery, except for appendectomy * Use of antihypertensive, cholesterol lowering, glucose-regulating drugs and corticosteroids * Use of antibiotics 3 months prior to the start or during the study * Use of probiotics and prebiotics 2 weeks prior to the start of the study/ during the study * Being on weight loss, gluten-free, lactose-free or vegan diet * Pregnancy, lactation or wish to become pregnant * Previous or current substance/ alcohol dependence or abuse * Hyper- or hypothyroidism * Allergy or intolerance to oat milk
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What it tests

  • with short-chain fatty acids enriched drink
  • unenriched oat drink
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Where

1 site
KU Leuven/ UZ Leuven
Leuven, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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