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โ† Trials
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Gut Microbiome in Orthopaedics: Revision Total Knee Arthroplasty

Recruitingn/aAges any - anyAllLondon Health Sciences Centre Research Institute โ€ฆ
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In plain words

What the trial is, and whether it could suit you

Many patients who receive knee replacement surgery must return for a revision (or repeat) surgery due to ongoing pain, stiffness, infection, or implant loosening. The role of the gut microbiome-the collection of bacteria and other microbes within the human gastrointestinal tract-is just beginning to be recognized in orthopaedics. The gut microbiome has been found to affect the immune response and bone regulation, potentially contributing to infection or loosening after total joint replacement. Antibiotics are regularly used in orthopaedic surgery to reduce the risk of infection, yet they might also harm gut microbiota and reduce their potentially beneficial effects. As a result, understanding the relationship between gut microbiota and surgical outcomes has become increasingly important. Therefore, this study aims to determine if there are differences in gut microbiota composition betwee

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Scheduled to undergo a revision TKA * Willing and able to comply with follow-up requirements * Ability to provide informed consent * Ability to read, write, and speak English Exclusion Criteria: * Pregnancy * Less than 3 months post-operation from primary surgery * Diagnosis of periprosthetic fracture * Scheduled for DAIR (debridement, antibiotics, and implant retention) revision surgery * Scheduled for stage 2 PJI revision
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What it tests

  • Revision Total Knee Arthroplasty
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Where

1 site
University Hospital
London, Canada
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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