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Mechanisms And Prognosis of Stroke-Heart Syndrome

Recruitingn/aAges 18 Years - anyAllChensheng Pan
NCT06954103 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The incidence of stroke-heart syndrome following acute stroke, which encompasses both acute ischemic stroke and acute intracerebral hemorrhage, is notably high and is strongly associated with increased mortality and poor outcomes in stroke patients. However, the underlying mechanisms remain unclear, and there are currently no effective prevention or treatment strategies. This study aims to elucidate the neuro-humoral mechanisms of stroke-heart syndrome through multimodal imaging and multi-omics blood analysis. Additionally, it seeks to observe the progression of stroke-heart syndrome and its impact on functional outcomes, cognitive abilities, and emotional issues post-stroke. The research is expected to uncover novel blood biomarkers and brain network mechanisms associated with stroke-heart syndrome, providing potential targets and theoretical foundations for pharmacological treatments o

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients admitted within 48 hours of onset, confirmed by CT/MRI as having a stroke (including acute ischemic stroke and hemorrhagic stroke). 2. Moderate-to-severe stroke with NIHSS ≥ 5. Exclusion Criteria: 1. Previous focal brain injury (such as stroke, brain surgery, traumatic brain injury, etc.). 2. Brain dysfunction caused by other major neurological disorders than stroke (such as brain tumors, epilepsy, Parkinson's disease, etc.). 3. Transient ischemic attack (TIA) and subarachnoid hemorrhage (SAH). 4. History of cardiac diseases (such as coronary heart disease, heart failure, severe arrhythmias, congenital heart disease, cardiac surgery, valvular heart disease, or undiagnosed significant cardiac symptoms). 5. Concomitant systemic diseases such as renal failure (eGFR \< 30), autoimmune disorders, severe infections, etc. 6. History of dementia, depression, or other psychiatric disorders. 7. Poor compliance and inability to cooperate with follow-up.
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What it tests

  • Not listed
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Where

1 site
Department of Neurology, Tongji hospital, Tongji medical college, Huazhong University of Science and Technology
Wuhan, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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