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Neuroimmunology Registry and Biobank

Recruitingn/aAges any - anyAllCharite University, Berlin, Germany
NCT06958341 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A variety of antineuronal antibodies have been detected in the cerebrospinal fluid (CSF) of patients with neurological diseases. This raises the question of whether these antibodies are disease-specific or merely an epiphenomenon of inflammatory processes in the brain. The registry was established with the following objectives: \[1\] Are antineuronal antibodies much more common than previously thought in various neurological disorders for which the etiology has not yet been elucidated? \[2\] Can further correlations, such as those between HSV infection and NMDA receptor autoimmunity, be identified? \[3\] Are these antibodies mainly non-specific epiphenomena or are they crucial for the pathogenesis? \[4\] What is the clinical course of patients with antineuronal antibodies and their response to therapy? These questions will be addressed in a broad immunohistological screening of a large

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Differential diagnosis: suspected neuroimmunological disease in which a lumbar puncture is indicated for further diagnosis and treatment decision 2. Individuals with unclear clinical diagnosis where additional CSF is to be collected for isolation of B cells and production of monoclonal antibodies. The clinical condition of the patients and his/her compliance have to allow an extra 2-3 ml of CSF to be collected. 3. Age: all age groups 4. Gender: patients of both sexes will be included Exclusion criteria: \[1\] Withdrawal of consent
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What it tests

  • Not listed
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Where

2 sites
Charité - Universitätsmedizin Berlin
Berlin, Germany
Universität Ulm
Ulm, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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