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Adjunctive Effect of Erythritol on Pocket Closure Rates

RecruitingNAAges 35 Years - anyAllUniversity of L'Aquila
NCT06958874 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This clinical trial is studying whether using erythritol powder during non-surgical periodontal treatment (deep cleaning) helps improve gum health in people with severe periodontitis. Participants with deep gum pockets (4 mm or more) receive standard treatment alone or standard treatment plus cleaning with erythritol powder. The goal is to evaluate if adding erythritol improves outcomes such as healing of gum pockets, bleeding, plaque levels, and gum attachment compared to standard treatment alone.

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📋 Eligibility rules (as published)
Inclusion Criteria: Adults aged 18 years or older Diagnosed with stage 3 or 4 periodontitis according to the 2017 classification Presence of at least 12 natural teeth Presence of periodontal pockets with probing depth ≥ 4 mm in non-adjacent teeth Good general health or stable systemic conditions (e.g., controlled diabetes) Exclusion Criteria: Use of antibiotics or anti-inflammatory drugs within 3 months prior to treatment Periodontal treatment in the previous 6 months Pregnancy or breastfeeding Current smokers of more than 10 cigarettes per day Allergies or intolerance to erythritol or any materials used in the treatment Systemic diseases or conditions that could influence periodontal healing (e.g., uncontrolled diabetes, immunodeficiency) Use of medications known to affect periodontal tissues (e.g., phenytoin, cyclosporine, calcium channel blockers)
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What it tests

  • Non-surgical periodontal therapy + sub-gingival air polishing
  • Non-surgical periodontal therapy alone
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Where

1 site
University of L'Aquila
L’Aquila, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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