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A Translational Study for Locoregional Recurrence of T4 Colon Cancer

Recruitingn/aAges 18 Years - anyAllNational Taiwan University Hospital
NCT06958926 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The outcome of T4 locally advanced colon cancer is poor when locoregional recurrence occurred. Previous studies had showed that the aggravation of T4 colon cancer is higher than N-positive colon cancer, contributing to staging paradox that outcomes of stage IIB/C are poorer than stage IIIA colon cancer and higher locoregional recurrence of stage IIB/C colon cancer. The phenomenon cannot be explained by radicality, lymph node harvested and adjuvant chemotherapy administration. To elucidate the cancerous aggravation of T4 colon cancer, the investigators should dive into the clinicopathology, metastatic mechanism and cancer biology. The investigators hypothesize that peritoneal spreading can be one of the metastatic routes of T4 colon cancer; however, few studies have addressed the finding and deserved investigation. Previous research have found that serum epigenetic alterations and cell-f

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📋 Eligibility rules (as published)
* Inclusion Criteria: 1. Age ≥ 18 years old 2. Diagnosed as colorectal cancer 3. Undergo radical colectomy or palliative colectomy, not limited to minimally invasive surgery or open surgery * Exclusion Criteria: 1. Age\<18 years old 2. Pregnancy 3. Patients with peritoneal dialysis 4. Patients who are unwilling to undergo colorectal surgery
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What it tests

  • Radical surgery for colon and rectum cancer
  • Radical surgery for colorectal cancer
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Where

1 site
National Taiwan University Hospital Hsin-Chu branch
Hsinchu, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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