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Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia

RecruitingNAAges 5 Years - anyAllInstituto Nacional de Enfermedades Respiratorias
NCT06959251 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

* Patients with primary ciliary dyskinesia (PCD) have trouble with clearing their bronchi from mucus, which in the long-term may produce severe damage to the lungs. Currently, there is no specific treatment for PCD beyond supportive measures such as airway hydration and postural drainage. * Glycine is an amino acid with anti-inflammatory properties that proved to be beneficial in another disease with problematic airway clearance, cystic fibrosis. * Magnesium participates in many crucial chemical reactions, including some that might favor fluidification and mobilization of mucus. Thiamine (vitamin B1) co-participates with magnesium in some mitochondrial enzymatic reactions occurring in the citric acid cycle. * Thus, oral supplements of glycine and magnesium+thiamine might improve symptoms and lung function of patients with PCD, and these effects may even be better if these supplements are

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Any sex. 2. Age of 5 years or more. 3. Diagnosis of primary ciliary dyskinesia (PCD) established according to international recommendations (Shapiro et al. Am J Respir Crit Care Med 2018;197(12):e24-e39, and Shapiro et al. Ped Pulmonol 2016;51:115-132). 4. Without respiratory exacerbations of PCD in the previous 30 days. 5. Without acute respiratory infection in the previous 30 days. 6. Informed consent letter signed by the patient (if the patient's age is 18 years or more). 7. Informed consent letter signed by the legal guardian, and assent letter signed by the patient (if the patient's age is \<18 years). Exclusion Criteria: 1\. Participation in other research protocol involving therapeutic measures. Elimination Criteria: 1\. None.
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What it tests

  • Glycine
  • Magnesium+thiamine
  • Placebo
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Where

1 site
Instituto Nacional de Enfermedades Respiratorias
Mexico City, Mexico
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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