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Modification of Inhibitory Control and Craving Through Transcranial Direct Current Stimulation (tDCS) as an Add-On Treatment for Substance Use Disorder

RecruitingNAAges 18 Years - 65 YearsAllCentral Institute of Mental Health, Mannheim
NCT06959342 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this project is to investigate the potential of transcranial direct current stimulation (tDCS) to reduce cognitive deficits and substance craving in individuals with substance use disorders (SUD), with a focus on alcohol use disorder (AUD). Patients of any gender between the ages of 18 and 65 are examined who are in our inpatient and day clinic settings for a standard detoxification treatment program. As there are conflicting findings regarding the effective settings for tDCS as an adjunctive treatment in SUD (e.g., effects on inhibitory control seem to be sensitive to current direction), the aim is to examine and compare three different active tDCS conditions, a sham tDCS condition (placebo), inhibition training, and a control group of patients receiving only standard detoxification treatment. The aim is to identify the optimal electrode placement and current direction to pos

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📋 Eligibility rules (as published)
Inclusion Criteria: * main diagnosis: alcohol use disorder according to DSM-5 * patients of any gender aged 18 to 65 * normal vision or correctable visual impairment. * sufficient ability to communicate verbally and in writing * ability to give fully informed consent after reviewing thorough written information Exclusion Criteria: * withdrawal of consent * severe internal, neurological, or psychiatric comorbidities (e.g., lifetime schizophrenia, bipolar disorder, or other severe mental disorders according to ICD-10 and DSM-5, such as severe depression or PTSD within the last 12 months). * Exclusion criteria for an EEG/tDCS examination (e.g. metal implants in the head, epilepsy, etc.) * severe withdrawal symptoms (CIWA-R \> 7) * alcohol intoxication (breath alcohol concentration \> 0 ‰) * Pharmacotherapy with psychoactive substances within the last 14 days (exceptions: clomethiazole or benzodiazepines used in withdrawal treatment, provided they were discontinued at least 3 days prior; antidepressants or anxiolytics taken at stable doses). * drug or alcohol use within the last 7 days * for women: pregnancy * suicidal tendencies or danger to others
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What it tests

  • Transcranial direct current stimulation (tDCS)
  • Inhibition Training
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Where

2 sites
Central Institute of Mental Health
Mannheim, Germany
Psychiatrisches Zentrum Nordbaden (Psychiatric Center Nordbaden)
Wiesloch, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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