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Modified Desmopressin (mDesmo) Using Cold-Kit for PET/CT

Recruitingn/aAges 5 Years - 75 YearsAllPost Graduate Institute of Medical Education and …
NCT06962202 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The incidence of Cushing syndrome (CS) is 1.2-3.2 cases per million per year, of which adrenocorticotropic Hormone (ACTH)-dependent disease comprises approximately 70-80% of cases. Among these, nearly 90% of ACTH-dependent CS are due to pituitary-dependent CS, known as Cushing disease (CD). The management of ACTH-dependent CS relies on distinguishing Cushing disease (or Corticotropinoma) from ectopic Cushing syndrome (ECS) followed by localization of the tumor in the sella. The diagnosis of CD is very challenging, especially when they are microadenomas (\<6 mm). Current imaging techniques, such as magnetic resonance imaging (MRI), have limitations in accurately delineating (sensitivity 60%) these tumors. Even if the lesion is detected inside the pituitary, the functionality of the tumor is questionable, as there can be innocent pituitary tumors which actually are not the cause of Cushing

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients diagnosed with endogenous Cushing's syndrome 2. Patients in the age group of 5 to 75 years. 3. Patients willing to give informed consent. Exclusion Criteria: 1. Patient with exogenous exposure to steroids 2. Ongoing pregnancy 3. Severe comorbid conditions that may interfere with the study.
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What it tests

  • Not listed
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Where

1 site
Post Graduate Institute of Medical Sciences
Chandigarh, India
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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