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The Effect of Personalized Exercise Interventions for the Prevention of Chemotherapy-induced Peripheral Neuropathy

RecruitingNAAges 18 Years - anyAllUniversiteit Antwerpen
NCT06962579 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and common side effect of neurotoxic cancer treatment. The most frequent symptoms include sensory disturbances and weakness in the hands and/or feet. CIPN can interfere with both daily activities and cancer treatment itself. Although there is proof of concept for physical activity as a preventive measure for CIPN, physical activity is currently not included in the international evidence-based guideline for the prevention of CIPN due to the need of larger sample-sized definitive studies. The aim of this project is, on the one hand, to investigate the preventive effect of an exercise program based on international physical activity guidelines on CIPN symptoms in patients with breast or colorectal cancer undergoing taxane- or platinum-based chemotherapy. On the other hand, the study will also explore how patients and health

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📋 Eligibility rules (as published)
Inclusion Criteria: * age above 18 years * a primary diagnosis of breast, gynaecological or colon cancer, without distant metastasis * been chemotherapy naïve * been scheduled for at least 12 weeks of taxane- or platinum-based chemotherapy without other neurotoxic chemotherapy Exclusion Criteria: * life expectancy of less than six months according to the patient's oncologist or designee * advanced stage of disease * having a known current neuropathy * having cognitive or physical limitations that contraindicate participation in a low- to moderate intensity home-based walking and progressive resistance program (determined by the patient's oncologist) * not able to read and understand Dutch * not able to provide informed consent * not able to participate during the entire study period * pregnancy
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What it tests

  • Exercise intervention
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Where

2 sites
Antwerp University Hospital
Edegem, Belgium
University Hospital Leuven
Leuven, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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