AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

โ† Trials
๐Ÿงช

Postoperative Electrical Muscle Stimulation Two

RecruitingNAAges 18 Years - anyAllUniversity of Nottingham
๐Ÿ’ฌ

In plain words

What the trial is, and whether it could suit you

Undesirable loss of skeletal muscle mass (atrophy) is a common feature of many diseases as well as ageing, bed rest and physical inactivity. Losing muscle can lead to a reduction in one's ability to perform physical activities, and reduce independence and overall health. Muscle mass loss occurs very quickly (i.e., within a few days) after surgery. The investigators previous work has shown that neuromuscular electrical stimulation (NMES) of the thigh muscles on one side of the body can help maintain muscle mass and strength on the stimulated side after surgery. Since then, additional work has been carried out to find the most effective form of stimulation to build muscle. The current study aims to use this refined stimulation protocol in a clinical trial on the wards after major abdominal surgery. The intervention will involve delivering stimulation to both thighs in the few days after

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Adult patients (age 18 or over at the time of diagnosis made at MDT (multi-disciplinary team meeting) * MDT outcome of colorectal or gastric cancer or non-invasive neoplasia (tissue-proven, or radiologically diagnosed and clinically suspected) with the intention to treat with curative abdominal surgery * Agreed management plan for open or minimally invasive (laparoscopic or robot assisted) segmental abdominal (colonic or gastric) resection at the Royal Derby Hospital * Sufficient mobility and fitness to complete normal ERAS (enhanced recovery after surgery) protocols following surgery * Basic conversational spoken English language * Ability to give informed consent Exclusion Criteria: * Upper GI (gastrointestinal) cancer requiring thoracotomy/thoracoscopy * Pre-existing neuromuscular disease (including Parkinsons disease) * Pacemaker, implantable cardiac defibrillator or other implanted nerve stimulator device * Metal prostheses or other metal-work in either upper legs (hip/knee/femur) * Dementia or other cognitive problem or language barrier causing an inability to follow instructions and operate NMES machine * Inability to give informed consent * Disability preventing completion of ERAS after surgery (requiring Zimmer frame/wheeled frame/wheelchair to mobilise or bed-bound) * Peripheral vascular disease * Epilepsy * Pre-existing diagnosis of chronic kidney disease or estimated glomerular filtration rate \<60 on screening visit * Pre-existing diagnosis of liver disease * Intubation or intensive care admission during study period (between day 0-5 post-op); (surgical high dependency unit patients will be included) * Return to theatre for surgical complication within first 5-days post operation * History of rhabdomyolysis * Pregnancy * Deep vein thrombosis within past 6-months * Allergy to whey protein * Patient refusal of whey protein products on grounds of dietary requirements or intolerance * Participating in another clinical trial concurrently or within the last 6 months * Known infection with blood borne virus
๐Ÿ’Š

What it tests

  • Neuromuscular Electrical Stimulation
  • Protein supplement drink
๐Ÿ“

Where

1 site
Royal Derby Hospital
Derby, United Kingdom
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy