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Study on Sex-specific, Individualized Dose Calculation of Contrast Agent in CT Examinations

RecruitingNAAges 18 Years - anyAllUniversity Hospital Augsburg
NCT06965790 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A large proportion of radiological CT examinations require the intravenous administration of iodine-containing X-ray contrast medium. According to current guidelines, the amount required for CT examinations in the (portal) venous phase is calculated on the basis of body weight (e.g. 0.2-0.4 g iodine/kg body weight), but a standardized application dose of the contrast agent is often also used. In earlier studies, the investigators found that the iodine contrast in vessels and organs achieved with a standardized amount of contrast agent differs significantly between women and men. On average, women showed around 10% higher iodine contrast than men of the same height and weight. The investigators attribute these differences to physiological, sex-specific differences in blood volume. For example, the blood volume of a woman 175 cm tall and weighing 75 kg is approx. 400 ml less than that of

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📋 Eligibility rules (as published)
Inclusion Criteria: * Presence of a justifying indication for a CT scan of the thorax and abdomen with application of intravenous contrast medium and a start delay corresponding to the portal venous contrast medium phase * Ability to give informed consent, as well as written and verbal consent to participate in the study available Exclusion Criteria: * Cardiorespiratory instability (as assessed by the attending physician) * Age \<18 years * Existing or suspected pregnancy * Known post hepatectomy and/or splenectomy * Lack of current height (in the same inpatient/outpatient hospital stay) or lack of possibility of height measurement * Lack of current daily body weight or inability to measure body weight * Height under 140 cm or over 220 cm * Body weight under 50 kg or over 120 kg * Contraindication to iodine-containing contrast medium (Allergy to contrast media containing iodine, Severe renal insufficiency (eGFR \< 30 ml/min), Hyperthyroidism)
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What it tests

  • contrast media (Imeron 350, active ingredient Iomeprol) volume according to sex-specific blood volume
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Where

1 site
University Hosptial Augsburg
Augsburg, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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