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Awake Prone Positioning of Patients Suffering Community Acquired Pneumonia Requiring Nasal High Flow Therapy

RecruitingNAAges 18 Years - anyAllUniversity Hospital, Tours
NCT06966310 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Community acquired pneumonia, in particular when requiring oxygen therapy because of acute hypoxemic respiratory failure and meeting acute respiratory distress syndrome (ARDS) criteria frequently leads to tracheal intubation and poor outcome. Among invasively mechanically ventilated patients with ARDS and presenting a PaO2/FiO2 ratio (arterial partial pressure of oxygen to inspired fraction of oxygen) of less than 150 mmHg, the prone position significantly reduces mortality and represents standard care (Guérin 2013). Among non-intubated COVID-19 patients, a subtype of viral community acquired pneumonia, a recent study showed that awake prone positioning reduces the composite outcome of intubation or death among patients requiring nasal high flow therapy. Furthermore, it favored weaning of nasal high flow therapy. Prone position in patients with non-COVID ARDS treated with high nasal fl

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients admitted to an intensive care unit or intermediate care unit * Suspicion of community acquired pneumonia (at least one of the 3 criteria): fever, cough, purulent expectoration * And abnormalities suggestive of pneumonia by chest X-ray or CT-scan * PaO2/FiO2 ratio \<300 mmHg (or equivalent SpO2/FiO2 i.e. \< 315 mmHg) under a minimum gas flow of 30 L/min. * Person affiliated to a French social security system or equivalent * Informed consent. Exclusion Criteria: * Positive SARS-COV2 test within the last 30 days * Indication for immediate intubation * Patients for whom a "do not intubate" decision has been made * Chest trauma or other contraindication to prone position * Patients with formal indication for non-invasive ventilation: exacerbation of chronic obstructive pulmonary disease, acute cardiogenic pulmonary oedema. * Pregnant or breastfeeding woman * Subjects who are under legal protection measure * More than 8h awake prone positioning prior to inclusion * More than 48h since intensive care unit or intermediate care unit admission.
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What it tests

  • Prone position
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Where

38 sites
Intensive care, University Hospital, Amiens
Amiens, France
Intensive care, University Hospital, Angers
Angers, France
Intensive care, University Hospital, Argenteuil
Argenteuil, France
Intensive care, University Hospital, Belfort
Belfort, France
Intensive care, University Hospital, Besancon
Besançon, France
Intensive care, University Hospital, Bethune
Béthune, France
Intensive care, University Hospital, Blois
Blois, France
Intensive care, University Hospital, Bordeaux
Bordeaux, France

…and 30 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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