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Evaluation of Fentanyl Transdermal Patch Absorption in Hemodynamically Unstable ICU Patients.

Recruitingn/aAges 18 Years - 70 YearsAllTel-Aviv Sourasky Medical Center
NCT06966869 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study investigates how well fentanyl is absorbed through the skin when delivered via a transdermal patch in critically ill surgical ICU patients. It compares hemodynamically stable patients with unstable patients who require vasopressors to maintain adequate blood pressure. Fentanyl blood levels will be measured over time to assess whether absorption is impaired in unstable patients. The goal is to determine whether transdermal fentanyl is a viable option for pain management in resource-limited ICUs or in situations where intravenous fentanyl is unavailable.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged 18-70 years. * Male or female patients. * Admitted to the surgical intensive care unit (ICU). * Indications for pain management using fentanyl. Exclusion Criteria: * No clinical indication for fentanyl analgesia (e.g., pain well controlled with non-opioid medications). * Known allergy or hypersensitivity to fentanyl. * Contraindications to fentanyl (e.g., severe constipation, hepatic failure) * Patients infected with multidrug-resistant organisms require high-level isolation (biosafety level 2 or higher). * Hemodynamically very unstable patients requiring \>20 drops/hour of norepinephrine (4 mg/50 mL), with or without vasopressin support.
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What it tests

  • Transdermal fentanyl patch
  • Transdermal fentanyl patch
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Where

1 site
Tel Aviv Medical Center
Tel Aviv, Israel
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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