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Double-blind Pilot Study on the Effect of Anionic Exposome Enrichment (Biow) on Recovery and Sleep Quality in Postoperative Patients

RecruitingPhase 1, Phase 2Ages 18 Years - anyAllInstituto de Investigación Sanitaria de la Fundac…
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In plain words

What the trial is, and whether it could suit you

Airborne nanoparticle exposure is increasingly recognized as a significant contributor to oxidative stress, mitochondrial dysfunction, and low-grade systemic inflammation-factors that impair postoperative recovery. The World Health Organization and European initiatives such as the Human Exposome Project have highlighted the clinical importance of the exposome, defined as the totality of environmental exposures influencing health throughout life. EOX is a CE-certified air regeneration system designed to modify the indoor exposome through a dual mechanism: advanced filtration and controlled emission of bioavailable anions using cold atmospheric plasma (CAP). Its multistage filter removes particulate matter, pathogens, and volatile organic compounds, while the anionic plasma phase modulates cellular oxidative balance and metabolic function. Experimental and clinical data indicate that exp

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged ≥18 years, regardless of sex. * Undergoing elective general surgery, preferably hepatobiliary procedures. * Hospitalized for at least 4 days postoperatively in Unit 69 (HUFJD). * Able to provide written informed consent. * Considered to have medium or high risk of oxidative stress or mitochondrial dysfunction. Exclusion Criteria: * Surgery within the previous 6 months, either outpatient or inpatient. * Diagnosed psychiatric or neurological disorders, including epilepsy. * Active progressive cancer or chronic inflammatory disease. * Cognitive impairment or inability to comply with study procedures. * BMI ≥30 kg/m² (obesity class I or higher).
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What it tests

  • EOX Anion-Enriched Hospital Room
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Where

1 site
Fundacion Instituto de Investigacion Sanitaria Fjd
Madrid, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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