Effect of Early Dexamethasone on Major Complications and All-cause Mortality in Severe Burns

Inclusion Criteria: * 18 years old ≤ Age ≤ 80 years old. * Total burn surface area ≥ 20%, measured by a trained expert upon admission * Invasive mechanical ventilation at the time of inclusion * Within 48 hours of the burn injury * Informed and signed written consent of the next-of-kin, legal representative (trusteeship, guardianship) or emergency procedure in the absence of a legal representative. * Affiliation with French social security system or beneficiary from such system Exclusion Criteria: * Imminent death and a do-not-resuscitate order * Medical history of hypersensitivity to dexamethasone and hypersensitivity to all of its excipients * Pregnancy (attested by a pregnancy test for women of childbearing age) and/or breastfeeding women * Participation to another interventional study involving a drug with known interactions with dexamethasone * Uncontrolled viral hepatitis or invasive fungal infection at the time of inclusion * Prolonged administration of steroids in the last 90 days (\>0.3 mg/kg/day of equivalent prednisolone) * Moderate-to-severe ARDS upon admission (according to Berlin definition criteria)