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Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia

RecruitingPhase 2Ages 18 Years - 85 YearsAllUniversity of Pennsylvania
NCT06968663 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with modified Constraint Induced Language Therapy (mCILT) is an effective treatment for aphasia when delivered in the subacute stage after stroke. The main questions this study aims to answer are: 1. Can TMS combined with mCILT improve overall speech? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and mCILT treatment? Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat subacute aphasia. Importantly, this trial will use electric field guided TMS to identify optimal and individualized stimulation intensity and site targeting. Participants will: * Complete a screening and medical intake to determine eligibility * Undergo MRI scans * Participate in 10 consecutive sessions (Monday-Friday) of TMS and

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📋 Eligibility rules (as published)
Inclusion Criteria: * Left hemisphere stroke resulting in aphasia * The stroke must have occurred between 2 and 6 weeks prior to enrollment * Must be able to understand the nature of the study, and give informed consent * English proficiency * Right-handed Exclusion Criteria: * History of serious and/or ongoing issues with substance abuse * Previous head trauma with loss of consciousness for more than 5 minutes * History of major psychiatric illness * Dementia, or other neurological conditions * Epilepsy, or seizure after the stroke event * Pacemaker * Diagnosis of tinnitus * Pregnancy
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What it tests

  • Transcranial Magnetic Stimulation (TMS)
  • Modified Constraint Induced Language Therapy (mCILT)
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Where

1 site
University of Pennsylvania
Philadelphia, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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