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Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing Hysterectomy

RecruitingPhase 3Ages 18 Years - anyFemaleWomen and Infants Hospital of Rhode Island
NCT06969326 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to determine if applying a single dose of topical estrogen cream in the operating room at the end of your hysterectomy (removal of uterus and cervix) improves the postoperative experience with bleeding and potential symptoms of dysphoria (a feeling of discomfort or distress). Topical estrogen cream is sometimes used if patients have increased risk of bleeding with surgery but is not currently utilized in a consistent way. This study aims to answer the question of whether this is a helpful treatment and should be included in standard postoperative care.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Gender diverse/transgender men 2. Age 18 or older 3. Have been on testosterone for at least 6 months with plan to undergo gender-affirming hysterectomy and are willing to be randomized to the use of topical estrogen postoperatively. 4. Have stable physical and mental health 5. No contraindications to estrogen therapy 6. Must be proficient in English or Spanish 7. Must have access to a device to receive text messages for study follow up 8. Must agree to allow their medical data to be used for research purposes Exclusion Criteria: 1. Under age 18 2. Have not been on testosterone for at least 6 months prior to planned hysterectomy 3. Known allergy to topical estrogen
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What it tests

  • Use of topical estradiol
  • No intervention
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Where

1 site
Women & Infants Hospital
Providence, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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