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Prevention and Treatment of AKI VEXUS Guided Post Cardiac Surgery

RecruitingNAAges 18 Years - anyAllOnassis Cardiac Surgery Centre
NCT06972082 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The main goal of this clinical trial is to learn if evaluation by ultrasound of venous congestion of liver and kidneys can guide treatment and prevent and treat acute kidney injury post cardiac surgery (CSA-AKI). Participants will: Be evaluated by liver and kidney veins ultrasound (treatment group) or a placebo post CSA-AKI. Fluid management for the treatment group will be based on a score that emerges from this evaluation (Venous Excess Ultrasound Score, VEXUS). Kidney function will be daily monitored and followed-up for 7 days and until discharge. Daily fluid balance and laboratory examination will be performed. Data will be recorded and collected and a statistical analysis will provide the results that will show or not a probable superiority of this evaluation comparing to the usual care.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients in the Cardiac Surgery ICU who develop acute kidney injury according to KDIGO criteria, within 48 hours of ICU admission after cardiac surgery * Elective and non-elective cardiac surgery. Exclusion Criteria: * Patient refusal * Severe chronic renal failure (GFR\<15 mL/min/m2 or on hemodialysis). * Critical preoperative condition (severe cardiogenic shock, resuscitated cardiac arrest, support with mechanical circulatory assist devices). * Liver cirrhosis or inferior vena cava obstruction. * Pregnancy. * Morbid obesity (BMI\>40 kg/m2). * Delirium or other condition that prevents the performance of an ultrasound study.
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What it tests

  • VEXUS
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Where

1 site
Onassis Cardiac Surgery Center
Athens, Greece
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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