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Metagenomics for Ocular Inflammation

Recruitingn/aAges any - anyAllMoorfields Eye Hospital NHS Foundation Trust
NCT06974162 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this study is to apply a diagnostic test called 'metagenomic sequencing' to identify the involvement of potential infections in patients with ocular inflammation, where this hasn't been detected by currently available standard testing. For many people with ocular inflammation, no cause is ever found for their disease. In some cases, an infection or infectious trigger is suspected, but currently available tests are inadequate. Metagenomic sequencing can identify almost every globally known infection (bacteria, virus, fungi, parasites) in a sample. Therefore, it has the potential to identify an infection that has caused or triggered ocular inflammation, and as a consequence may help to identify specific treatments. It has the potential to improve our understanding of how to diagnose and treat people with this problem. This study will allow us to test the technique that has been

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. 18 years of age or older with the capacity to consent 2. Standard of care has not determined a clinical diagnosis 3. Active ocular inflammation with risk of visual loss 4. Clinically suspected infectious or para-infectious cause of ocular inflammation Exclusion Criteria: 1. Contraindication to ocular fluid sampling 2. Where an urgent result within 5 days is clinically required
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What it tests

  • Metagenomic sequencing of aqueous humor
  • Ocular Imaging
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Where

1 site
Moorfields Eye Hospital NHS Foundation Trust
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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