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Evaluation of Genetic Abnormalities Amongst Calcium Phosphate Stone Formers

RecruitingNAAges 18 Years - 90 YearsAllRyan L Steinberg
NCT06974357 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Kidney stones continue to affect more and more people in the United States with the most recent estimate being 1 in 9 people will develop a stone in their life. While family history is a known risk factor for stone disease, it remains unclear whether this is related to learned dietary habits or a truly inheritable genetic condition. Known inheritable genetic conditions linked to stone formation are uncommon, and thus, routine genetic testing is not currently recommended by any major urologic organizations. Patients who form calcium phosphate predominant stones, a less common type of stone composition, tend to have alkaline urine pH which suggests that the kidneys are unable to rid the body of acid. Management of such patients for stone prevention can be difficult. The Iowa Institute for Human Genomics is one of only a handful of commercial labs which offers genetic testing for stone dise

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📋 Eligibility rules (as published)
Inclusion Criteria: * Any patient, aged 18-90 and not incarcerated, under the care of a urologist at UIHC with known kidney stone composition including \>=60% calcium phosphate and baseline 24 hour urine pH of \>=6.3 Exclusion Criteria: \- Any patient over the age of 90 years old, incarcerated or without any evidence of calcium phosphate stone composition * No struvite component on prior stone analysis * No bacteria with urease producing organism at time of stone removal * No history or evidence of systemic acidosis * No use of acetazolamide, topiramate, zonisamide, valproic acid * Stage \>=3 CKD (GFR\<60) * Hepatic disease * Pregnancy * History of osteoporosis
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What it tests

  • Genetic testing
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Where

1 site
University of Iowa
Iowa City, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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