Open, Non-comparative Pilot Study to Evaluate the Safety and Efficacy of Intraovarian Plasma Rich in Growth Factors (PRGF) in Patients With Low Ovarian Reserve

Inclusion Criteria: * Women of childbearing age as defined by the CTFG\*. * Women in group 3 and 4 of the POSEIDON classification for low reserve: * POSEIDON 3: patients ˂ 35 years of age with decreased ovarian reserve (AMH \<1.2 ng/ml, AFC \<5). * POSEIDON 4: patients ≥ 35 years with decreased ovarian reserve (AMH \<1.2 ng/ml, AFC \<5). * Patients with at least one ovary. * Infertility of more than 1 year duration. * Provision of safe ovarian access on the day of the puncture. * They agree to participate and to give their written consent. Exclusion Criteria: * Have a diagnosis of clinical ovarian insufficiency - Patients with an ongoing pregnancy - Patients with a clinical diagnosis of ovarian failure * Patients with ongoing pregnancy * Current or previous IgA deficiency, * Ovarian failure secondary to identified genetic causes. * Presence of pelvic adhesions after abdominal surgery. * Chronic use of aspirin, NSAIDs or anticoagulants. * Diseases that alter platelet number or function. * Psychiatric disorder that precludes participation in the study (including active substance abuse or dependence). * Obesity (BMI ≥ 30). * Current female smokers (≥ 15 cigarettes per day) - Current smoking (≥ 15 cigarettes per day) * Patients affected by neoplastic disease * Severe male factor infertility