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The Developmental Origins of Obesity

RecruitingNAAges 18 Years - anyFemalePontificia Universidad Catolica de Chile
NCT06981676 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Pregestational obesity (PGO, BMI ≥30) is a significant independent risk factor for the development of obesity in childhood and adolescence. Notably, elevated levels of IL-6 and leptin have been found in the cord blood of offspring born to women with PGO, along with increased body fat. Both our research and that of others have shown an upregulation of pro-inflammatory genes in cord blood monocytes and alterations in innate immune function, including a blunted response to pro-inflammatory stimuli. However, it remains unclear whether these effects are due to an altered immune response in differentiated immune cells or if they are programmed earlier in gestation, during the progenitor cell stage. Long-chain polyunsaturated fatty acids (LCPUFAs) are crucial for cellular function, acting as precursors to membrane components and signaling molecules involved in cardiovascular, metabolic, and im

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📋 Eligibility rules (as published)
Inclusion Criteria: * First prenatal visit \<14 weeks gestation * Pregestational BMI between 18.5 and 24.9 for the NW groups and BMI \>30 for the PGO groups, * To have singleton pregnancy, * ≥18 years of age and plan to deliver at the Hospital Clínico UC- Christus Exclusion Criteria: * Preexisting diabetes * GDM * Preeclampsia, * Multiple gestations * Chronic cardio-respiratory disorder or neurological o genetic defects of the fetus * History of an eating disorder, food allergy, * Any high-risk pregnancy condition (MINSAL 2015)
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What it tests

  • DHA and EPA
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Where

1 site
Red Salud UC Christus Hospital
Santiago, Chile
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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