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Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Kidney Function in Advanced Chronic Kidney Disease

RecruitingPhase 3Ages 18 Years - anyAllAin Shams University
NCT06982079 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to evaluate whether dapagliflozin can reduce the risk of worsening kidney function or death from cardiovascular or renal causes in adults with advanced chronic kidney disease (CKD), with or without type 2 diabetes. The main questions it aims to answer are: 1. Does dapagliflozin reduce the rate of decline in kidney function or progression to end-stage kidney disease in adults with advanced CKD? 2. Does dapagliflozin reduce the risk of death from cardiovascular or renal causes in patients with advanced CKD? Researchers will compare dapagliflozin to a placebo to see if dapagliflozin improves kidney and cardiovascular outcomes in this high-risk population.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients aged eighteen or older. * Patients with advanced chronic kidney disease (i.e., eGFR \< 20 mL/min/1.73m2)not on dialysis Exclusion Criteria: * Autosomal dominant polycystic kidney disease (ADPKD). * Type 1 diabetes mellitus * Patients on SGLT2 inhibitors. * History of ketoacidosis in the last 3 months. * Known hypersensitivity to SGLT2 inhibitors. * Known hepatic impairment. * Pregnant or breastfeeding females.
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What it tests

  • Dapagliflozin 10 mg
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Where

1 site
Ain Shams University Hospitals
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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