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Accelerated TMS for Freezing of Gait in Parkinson's Disease

RecruitingNAAges 50 Years - 80 YearsAllMedical University of South Carolina
NCT06982638 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn whether a personalized brain stimulation method called repetitive transcranial magnetic stimulation (rTMS), combined with walking exercises, is a practical and tolerable approach to help people with Parkinson's disease who experience freezing of gait (FOG). FOG is a disabling symptom where people temporarily feel stuck and unable to start walking, even though they want to move. The main questions this study aims to answer are: Can people with Parkinson's disease and FOG tolerate this combined rTMS and walking training procedure? Can researchers successfully enroll and retain participants for this multi-visit intervention? Does the combination of rTMS and gait training show early signs of improving gait and reducing freezing episodes? This study does not include a comparison or placebo group. All participants will receive the same intervent

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. 50-80 years of age 2. diagnosis of PD based on UK Brain Bank diagnostic criteria 55 3. presence of FOG defined as a score of 1 on part 1 of the nFOGQ in which a video showing different types of freezing is played for the patient, a score of 1 represents a positive response of having experienced such an episode over the last month 4. no dopaminergic medication changes in the month prior 5. observed FOG rated as \>1 in item 3.11 of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Exclusion Criteria: 1. a history of other significant gait impairment unrelated to PD (e.g. orthopedic deformities) 2. inability to complete gait assessments (timed up and go task) without assistance or assist devices 3. barriers to making contact between the TMS coil and the skin (e.g. braids that cannot be removed) 4. failing to meet all criteria on a standardized MRI/TMS safety screening: This includes, but is not limited to, the presence of claustrophobia, implanted electronic devices (e.g., pacemakers), metallic objects or fragments (e.g., bullets), and non-removable hair clips or piercings. 5. individuals with a diagnosis of psychosis or any other cognitive impairments that would make them unable to understand and follow study instructions or to consent for themselves. 6. pregnancy 7. individuals with a history of seizure
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What it tests

  • TMS+ Gait training
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Where

1 site
Medical University of South Carlina
Charleston, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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