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Randomized Trial Comparing Fecal Testing (FIT) to Colonoscopy for Post-polypectomy Surveillance

RecruitingNAAges 40 Years - 75 YearsAllSorlandet Hospital HF
NCT06983639 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

From observational studies, it is know that the risk of developing colorectal cancer after polyp removal is lower if the patients adheres to surveillance recommendations. However, colonoscopy is burdensome for patients and colonoscopy availability is limited in many parts of the world. In addition, more than half of surveillance colonoscopies are without any findings. The trial investigates whether surveillance using fecal testing for blod is as good as colonoscopy after removal of colorectal polyps.

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📋 Eligibility rules (as published)
Inclusion Criteria: * High-quality baseline colonoscopy with adequat cleansing and cecal intubation * Remocval of at least one advanced adenoma * Clean colon (all polyps removed) * Signed informed consent Exclusion Criteria: * Colorectal cancer * History of surgical colon resection for any reason * Genetic cancer syndrome (adenomatous or serrated polyposis syndrome; Lynch or Lynch-like syndrome) * ≥ 10 adenomas at baseline colonoscopy (cumulative) * History of advanced serrated lesion, defined as SSL≥ 10mm or with dysplasia * Inflammatory bowel disease * On-going palliative care for any reason
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What it tests

  • Fecal occult blood testing
  • Colonoscopy
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Where

1 site
Sørlandet sykehus HF
Arendal, Norway
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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