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Comparing Antibiotic Treatment Strategies for Children With Pneumonia in Outpatient Settings: (STAMPP)

RecruitingNAAges 12 Months - 71 MonthsAllAnn & Robert H Lurie Children's Hospital of Chica…
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to determine if a "watch and wait" antibiotic strategy, called Safety Net Antibiotic Prescribing (SNAP), can safely reduce unnecessary antibiotic use while ensuring that children diagnosed with community-acquired pneumonia get better from their illness. The main aims of this study are: * To compare the effectiveness of SNAP versus immediate antibiotic prescribing in children with mild community-acquired pneumonia (CAP) * To identify which patient groups benefit most from the SNAP strategy * To identify factors that shape implementation of each prescribing strategy. Researchers will compare the SNAP strategy (where parents or guardians are instructed to give antibiotics only if their child is not improving after 72 hours, or sooner if they are worsening) to the immediate antibiotic prescribing strategy (where parents or guardians are instructed to give

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Aims 1 and 2: * Presenting with signs and symptoms of lower respiratory tract infection * Diagnosed with community-acquired pneumonia (CAP) by a clinician * The treating clinician intends to prescribe antibiotics for CAP, AND * Well enough, as determined by the clinician at the time of the study enrollment visit, to be managed as an outpatient. * Aim 3: * Parent/guardian of child enrolled in the trial, OR * Clinician who makes prescribing decision at the study site, OR * Other practice-based parties (e.g. nurses, pharmacists, medical assistants, practice leaders) at study sites who can comment on the implementation of each prescribing strategy. Exclusion Criteria: * Aims 1 and 2: * Hospitalization within the previous 7 days * Oxygen saturation below 90%, if measured * Incomplete immunization status (e.g., lacking at least 3 doses of the pneumococcal vaccines, typically given as part of the 2-, 4-, and 6-month vaccinations) * Chronic medical conditions that increase the risk of bacterial CAP (e.g., chronic lung disease, cystic fibrosis, sickle cell disease), * Substantially immunocompromised status (e.g., immunodeficiency, active cancer treatment, organ transplant with concurrent immunosuppressive agents) * Receipt of oral or parenteral antibiotics within the previous 7 days * Diagnosis of complicated pneumonia (e.g., empyema, lung abscess) * Known bacterial source of infection warranting immediate antibiotics * Pneumonia diagnosis within the previous 6 months, OR * Prior enrollment in the trial * Inability of the parent or guardian to speak English or Spanish * Aim 3: * Inability of the parent or guardian to speak English
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What it tests

  • Immediate Antibiotic Prescribing Group Instructions
  • Safety Net Antibiotic Prescribing (SNAP) Group Instructions
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Where

4 sites
Children's Healthcare of Atlanta
Atlanta, United States
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, United States
Children's Hospital of Philadelphia
Philadelphia, United States
Primary Children's Hospital
Salt Lake City, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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