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CKD Cachexia and Gut Microbiome

Recruitingn/aAges 18 Years - anyAllUniversité Catholique de Louvain
NCT06986265 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cachexia is common in patients with chronic kidney disease (CKD) and is associated with increased morbidity and mortality. Cachexia is a complex syndrome, in which inflammation and retention of uremic toxins are two main contributing factors. In this context, the role of the gut microbiome in CKD cachexia and the potential benefit of increasing the dialysis dose have been poorly explored. Here the investigators propose to study the links between cachexia and the gut microbiome, in association with inflammation and uremic toxins, in dialysis. The specific objectives are the followings: 1. Set up a prospective cohort of deeply characterized kidney failure patients treated with hemodialysis (in-center, self-care dialysis in a satellite unit and at home) and peritoneal dialysis, including evaluation of cachexia, body composition, collection of feces and blood to characterize the gut microb

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * Diagnosis of kidney failure (stage V) * Maintenance dialysis for at least 3 months * Understanding of the trial procedures and ability to adhere to the trial protocol Exclusion Criteria: * Severe nonadherence to the dialysis procedure * Life expectancy below 1 year * Chronic inflammatory disease of the digestive tract (Crohn's disease, ulcerative colitis) * Bariatric surgery * Active cancer * Pregnancy * Antibiotics consumption in the month preceding the inclusion * Gastro-intestinal surgery, colonoscopy, or probiotics consumption in the 3 months preceding the inclusion * Drugs influencing body composition initiated ≤ 1 month : systemic corticosteroids, anabolic drugs as insulin or testosterone, post-menopausal hormone therapy, injectable contraceptives. * Known endocrinological disorders potentially leading to hypo- or hypermetabolism, untreated or treated for ≤ 1 month : disorders of thyroid gland, adrenal glands... * Patients under weight loss drugs : GLP1 agonists, orlistat
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What it tests

  • Collection of clinical data and biological sampling
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Where

2 sites
Cliniques universitaires Saint-Luc
Brussels, Belgium
UCLouvain
Brussels, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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