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Dexamethasone Palmitate for PONV After Craniotomy

RecruitingNAAges 18 Years - 65 YearsAllBeijing Tiantan Hospital
NCT06988124 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Dexamethasone is almost one of the most commonly used drugs for postoperative nausea and vomiting (PONV) prevention. However, PONV is still a complex problem to be solved; for example, even with preoperative dexamethasone administration, there are still some patients undergoing craniotomy still experience PONV within 24 hours postoperatively. Compared to dexamethasone, dexamethasone palmitate has a long-lasting anti-inflammatory effect, 2-5 times that of traditional water-soluble dexamethasone, with fewer adverse effects. This trial aims to assess the effect and safety of preoperative dexamethasone palmitate on PONV after craniotomy.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged 18 to 65 years; * Providing written informed consent; * Perform elective craniotomy undergoing general anesthesia. Exclusion Criteria: * Known to be allergic to dexamethasone; * Any systemic glucocorticoids within 3 months before trial entry; * History of severe heart disease, liver/kidney failure, or systemic rheumatic diseases (rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, et al); * Cognitive impairment or severe mental illness; * Uncontrolled diabetes or infectious diseases; * Pregnancy or breastfeeding.
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What it tests

  • Dexamethasone Palmitate
  • Dexamethasone
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Where

1 site
Fang Luo
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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