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A Hybrid 1 Effectiveness-Implementation Trial of Partner-Assisted Prolonged Exposure for PTSD

RecruitingNAAges 18 Years - anyAllUnited States Department of Defense
NCT06990191 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

PTSD occurs in up to 17% of post-9/11 US Service Members and is associated with long-term functional impairment, family problems, unemployment, and suicidality. Trauma-focused therapies (TFTs), such as Prolonged Exposure (PE), result in significant relief for many. Yet, TFTs are not equally effective for everyone. An important minority (\~40%) will retain their PTSD diagnoses after treatment, and many discontinue treatment prematurely, especially post-9/11 Service Members. TFTs are also more effective in addressing symptoms than psychosocial functioning. More work is needed to improve the consistency and potency of TFTs. Partnering with significant others may provide a powerful method for helping individuals get more out of their PTSD treatment. Observational research shows that relationship factors can help patients initiate, stay in, and experience greater benefit from PTSD treatment.

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Post-9/11 Veteran Enrolled in VHA * 1 \> mo stable medication * Committed relationship 6+ months * DSM-5-R PTSD Diagnosis Exclusion Criteria: * Imminent suicidality/homicidally * Mania, psychosis, or severe substance use disorder, past 3 mos * Severe cognitive impairment * Severe intimate partner violence in last 6 months * Fear of or intimidation by partner * Partner screens positive for PTSD
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What it tests

  • Partnered Prolonged Exposure (PPE)
  • Prolonged Exposure (PE)
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Where

4 sites
Phoenix VA Healthcare System
Phoenix, United States
San Diego VA Healthcare System
San Diego, United States
Minneapolis VA Healthcare System
Minneapolis, United States
Charleston VA Healthcare System
Charleston, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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