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A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

RecruitingPhase 2Ages 18 Years - 79 YearsAllPfizer
NCT06991257 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
This study is seeking participants who are: Key Inclusion Criteria include: * aged 18 years to \< 80 years * clinically confirmed to have a diagnosis of heart failure for at least 3 months * New York Heart Association Class II-IV symptoms * left ventricular ejection fraction greater than 40% * Kansas City Cardiomyopathy Questionnaire-23 Total Symptom Score \< 85 * Six-minute walking distance greater than 75 meters Key Exclusion Criteria include: * Type 1 diabetes mellitus, liver cirrhosis or any condition that can possibly affect how the medicine is absorbed into the body. * Major surgery scheduled for the duration of the study, affecting walking ability in the opinion of the study doctor. * History of heart transplantation, or currently listed for a heart transplant, or current planned use of IV vasodilators and/ or inotropes * Prior intolerance/known hypersensitivity to an SGLT2 inhibitor or contraindication to an SGLT2 inhibitor
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What it tests

  • Placebo
  • Low Dose PF-07328948
  • Medium Dose PF-07328948
  • High Dose PF-07328948
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Where

150 sites
National Heart Institute
Beverly Hills, United States
Orange County Research Center
Lake Forest, United States
Comprehensive Cardiovascular Care
Santa Maria, United States
FOMAT Medical Research
Santa Maria, United States
Jacksonville Center for Clinical Research
Jacksonville, United States
Infinite Clinical Research
Miami, United States
Flourish Research Acquisition, LLC dba Flourish Research - North Miami
Miami, United States
Amavita Research Services
North Miami Beach, United States

…and 142 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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