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Neuroprotection Bundles For Comatose Survivors Following Cardiac Arrest

RecruitingNAAges 18 Years - 80 YearsAllXiangya Hospital of Central South University
NCT06992843 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The investigators designed LAPTOPS to determine the effectiveness of a goal-directed neuroprotection bundles of active management including body temperature,PaCO2,PaO2,position,Blood glucose ,blood sodium,Blood pressure and Lactate vs. usual care in adult post-cardiac arrest care. LAPTOPS is a large-scale pragmatic clinical trial to provide reliable evidence over the effectiveness of a widely applicable goal-directed care bundle in acute phase of adult post-cardiac arrest care.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years and \< 80 years * Patients of in-hospital or out-of-hospital cardiac arrest who have returned -spontaneous circulation (ROSC) after cardiopulmonary resuscitation and do not require CPR for more than 20 minutes; * Patients who are unconscious after ROSC, defined as FOUR motor response score \< 4 points or GSC ≤ 8 points; * Family members or legal representatives signed informed consent. Exclusion Criteria: * Unwitnessed cardiac arrest, estimated time from cardiac arrest to start of CPR \> 30 minutes; * Time from cardiac arrest to ROSC \> 60 minutes; * Patients who woke up immediately after ROSC by CPR; * End-stage diseases; * Cardiac arrest considered to be caused by neurological diseases; * The patient was in a vegetative state before cardiac arrest; * The interval from the onset of cardiac arrest to enrollment is \>72 hours .
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What it tests

  • Goal-directed care bundle for neuroprotection
  • Usual Care
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Where

1 site
Xiangya hospital，Central South University
Changsha, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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