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A Study to Investigate the Safety and Efficacy of KQB168 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

RecruitingPhase 1Ages 18 Years - anyAllKumquat Biosciences Inc.
NCT06994806 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn if KQB168 works to treat advanced solid tumor cancer in adults. It will also learn about the safety of KQB168. The main questions it aims to answer are: * What is the safe dose of KQB168 by itself or in combination with pembrolizumab? * Does KQB168 alone or in combination with pembrolizumab decrease the size of the tumor? * What happens to KQB168 in the body? Participants will: * Take KQB168 daily, alone or in combination with pembrolizumab * Visit the clinic about 8 times in the first 8 weeks, and then once every 3 weeks after that

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📋 Eligibility rules (as published)
Inclusion Criteria: * Histologically confirmed diagnosis of solid tumor malignancy. * Unresectable or metastatic disease that has progressed on immunotherapy. * No available treatment with curative intent * Adequate organ function * Measurable disease per RECIST v1.1 Exclusion Criteria: * Active primary central nervous system tumors * Cardiac abnormalities * History of lung diseases * Any condition that may impair drug absorption or prevent oral dosing * Known history of immune-mediated colitis and uncontrolled autoimmune diseases
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What it tests

  • KQB168
  • Pembrolizumab
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Where

15 sites
Mayo Clinic - Phoenix
Phoenix, United States
USC Norris Comprehensive Cancer Center
Los Angeles, United States
Sarah Cannon Cancer Institute at HealthONE
Denver, United States
Yale Cancer Center- New Haven
New Haven, United States
Mayo Clinic - Jacksonville
Jacksonville, United States
Florida Cancer Specialists - Sarasota
Sarasota, United States
University of Iowa
Iowa City, United States
Mayo Clinic - Rochester
Rochester, United States

…and 7 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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